Journal
NEUROSURGICAL FOCUS
Volume 34, Issue 5, Pages -Publisher
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2013.2.FOCUS1315
Keywords
intracerebral hemorrhage; nicotinic acetylcholine receptor; alpha-7 agonist
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Funding
- Clinical Research Fellowship from the Doris Duke Charitable Foundation
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Intracerebral hemorrhage (ICH) is the most deadly and least treatable subtype of stroke, and at the present time there are no evidence-based therapeutic interventions for patients with this disease. Secondary injury mechanisms are known to cause substantial rates of morbidity and mortality following ICH, and the inflammatory cascade is a major contributor to this post-ICH secondary injury. The alpha-7 nicotinic acetylcholine receptor (alpha 7-nAChR) agonists have a well-established antiinflammatory effect and have been shown to attenuate perihematomal edema volume and to improve functional outcome in experimental ICH. The authors evaluate the current evidence for the use of an alpha 7-nAChR agonist as a novel therapeutic agent in patients with ICH.
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