Journal
NEUROSURGICAL FOCUS
Volume 28, Issue 1, Pages -Publisher
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2009.10.FOCUS09207
Keywords
microRNA; glioma; medulloblastoma; cancer stem cell
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MicroRNAs (miRNAs) are now recognized as the primary RNAs involved in the purposeful silencing of the cell's own message. In addition to the established role of miRNAs as developmental regulators of normal cellular function, they have recently been shown to be important players in pathological states such as cancer. The authors review the literature on the role of miRNAs in the formation and propagation of gliomas and medulloblastomas, highlighting the potential of these molecules and their inhibitors as therapeutics. (DOI: 10.3171/2009.10.FOCUS09207)
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