Journal
NEUROSURGERY CLINICS OF NORTH AMERICA
Volume 23, Issue 4, Pages 639-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.nec.2012.06.006
Keywords
Cushing syndrome; Cushing disease; Transsphenoidal surgery; Adrenocorticotropin; Hypercortisolism
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Cushing disease (CD) is caused by overproduction of adrenocorticotropin by a pituitary adenoma (or, rarely, carcinoma). The diagnosis of CD requires distinguishing it from other hypercortisolemic states with a thorough endocrine workup. CD remains a primarily surgical disease, with remission rates of 70% to 95% following microscopic or endoscopic transsphenoidal surgery.
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