Journal
NEUROSURGERY CLINICS OF NORTH AMERICA
Volume 20, Issue 2, Pages 219-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.nec.2009.04.004
Keywords
Gene therapy; Convection enhanced delivery; Restorative neurosurgery
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Funding
- NINDS NIH HHS [F32 NS064692-01] Funding Source: Medline
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Gene therapy for brain disorders is one of the most promising frontiers in the practice of restorative neurosurgery. There are significant experimental gene therapy initiatives underway that have led to currently active clinical trials using direct intracerebral delivery of viral vectors, and these treatments have been reported as safe and well tolerated. In the future, other clinical trials will likely use viral vectors to transfer genes that bestow on recipient tissue a desired enzymatic or neurotrophic activity relevant to the treatment of other neurodegenerative diseases, stroke, and traumatic brain injury.
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