Journal
NEUROSURGERY
Volume 72, Issue 4, Pages 501-510Publisher
OXFORD UNIV PRESS INC
DOI: 10.1227/NEU.0b013e3182846e63
Keywords
Biomarkers; Extracellular vesicles; Exosomes; Microvesicles
Categories
Funding
- Exosome Diagnostic
- ABC2 foundation
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The discovery that tumor-derived proteins and nucleic acids can be detected in nano-sized vesicles in the plasma and cerebrospinal fluid of patients afflicted with brain tumors has expanded opportunities for biomarker and therapeutic discovery. Through delivery of their contents to surrounding cells, exosomes, microvesicles, and other nano-sized extracellular vesicles secreted by tumors modulate their environment to promote tumor growth and survival. In this review, we discuss the biological processes mediated by these extracellular vesicles and their applications in terms of brain tumor diagnosis, monitoring, and therapy. We review the normal physiology of these extracellular vesicles, their pertinence to tumor biology, and directions for research in this field.
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