Journal
NEUROSURGERY
Volume 64, Issue 3, Pages 423-428Publisher
OXFORD UNIV PRESS INC
DOI: 10.1227/01.NEU.0000338067.83059.EB
Keywords
Cerebral aneurysm; Cerebral vasospasm; Edaravone; Free radical scavenger; Subarachnoid hemorrhage
Categories
Ask authors/readers for more resources
OBJECTIVE: It is hypothesized that cerebral vasospasm after aneurysmal subarachnoid hemorrhage (SAH) is induced by free radicals released from a subarachnoid clot. This study therefore investigated the effect of a new free radical scavenger, edaravone, in the treatment of patients with aneurysmal SAH. METHODS: Ninety-one patients with aneurysmal SAH participated in this study and were randomized into a control group (n = 42) and an edaravone-treated group (n 49). The difference between the 2 groups in terms of incidence of delayed ischemic neurological deficits (DINDs) and cerebral infarction caused by vasospasm, and Glasgow Outcome Scale score at 3 months after SAH were statistically analyzed. RESULTS: The incidence of DINDs was 21% in the control group and 10% in the edaravone-treated group, yet there was no statistically significant difference between the 2 groups (P = 0.118). In patients with DINDs, the incidence of cerebral infarction caused by vasospasm was 66% in the control group and 10% in the edaravone-treated group (P = 0.028), whereas the incidence of poor outcome caused by vasospasm was 21 % in the control group and 10% in the edaravone-treated group (P = 0.046). CONCLUSION: We found a trend toward a lesser incidence of DINDs and a lesser incidence of poor outcome caused by cerebral vasospasm in edaravone-treated patients. it might therefore be suggested that edaravone is a useful agent for the treatment of aneurysmal SAH.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available