Journal
NEUROSIGNALS
Volume 20, Issue 3, Pages 132-146Publisher
KARGER
DOI: 10.1159/000336542
Keywords
Adult neurogenesis; Brain injuries; Cell migration; Chemokines; Growth factors; Inflammation; Neural precursor cells
Funding
- Victorian Neurotrauma Initiative and Transport Accident Commission
- National Health and Medical Research Council
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Brain injury following stroke or trauma induces the migration of neuroblasts derived from subventricular zone neural precursor cells (NPCs) towards the damaged tissue, where they then have the potential to contribute to repair. Enhancing the recruitment of new cells thus presents an enticing prospect for the development of new therapeutic approaches to treat brain injury; to this end, an understanding of the factors regulating this process is required. During the neuro-inflammatory response to ischemic and traumatic brain injuries, a plethora of pro- and anti-inflammatory cytokines, chemokines and growth factors are released in the damaged tissue, and recent work indicates that a variety of these are able to influence injury-induced migration. In this review, we will discuss the contribution of specific chemokines and growth factors towards stimulating NPC migration in the injured brain. Copyright (C) 2012 S. Karger AG, Basel
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