Journal
NEUROSIGNALS
Volume 19, Issue 3, Pages 151-162Publisher
KARGER
DOI: 10.1159/000328508
Keywords
Subthalamic nucleus; Local field potential; Deep brain stimulation; Chronic recording; Hyperacute recording; Parkinson's disease; Beta activity; Adaptive deep brain stimulation system
Funding
- ERANET-Neuron Grant 'PhysiolDBS' [Neuron-48-013]
- Fondazione IRCCS Ca' Granda
- Ospedale Maggiore Policlinico (Milan, Italy)
- Universita degli Studi di Milano (Italy)
- Ministero della Sanita (Italy)
- Ministero dell'Universita e della Ricerca Scientifica e Tecnologica (Italy)
Ask authors/readers for more resources
In the past years, local field potential (LFP) signals recorded from the subthalamic nucleus (STN) in patients undergoing deep brain stimulation (DBS) for Parkinson's disease (PD) disclosed that DBS has a controversial effect on STN beta oscillations recorded 2-7 days after surgery for macroelectrode implantation. Nothing is known about these DBS-induced oscillatory changes 30 days after surgery. We recorded STN LFPs during ongoing DBS in 7 patients with PD, immediately (hyperacute phase) and 30 days (chronic phase) after surgery. STN LFP recordings showed stationary intranuclear STN beta LFP activity in hyperacute and chronic phases, confirming that beta peaks were also present in chronic recordings. Power spectra of nuclei with significant beta activity (54% of the sample) showed that it decreased significantly during DBS (p = 0.021) under both recording conditions. The time course of beta activity showed more evident DBS-induced changes in the chronic than in the hyperacute phase (p = 0.014). DBS-induced changes in STN beta LFPs in patients undergoing DBS in chronic phase provide useful information for developing a new neurosignal-controlled adaptive DBS system. Copyright (C) 2011 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available