Journal
NEUROSIGNALS
Volume 17, Issue 1, Pages 23-41Publisher
KARGER
DOI: 10.1159/000186688
Keywords
G protein; Go; G-protein-coupled receptors; Signal transduction; Effectors; Central nervous system; Alzheimer's disease
Funding
- National Institute of Diabetes and Digestive and Kidney Diseases [DK069771]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK069771] Funding Source: NIH RePORTER
Ask authors/readers for more resources
Go is the most abundant G protein in the central nervous system, where it comprises about 1% of membrane protein in mammalian brains. It functions to couple cell surface receptors to intercellular effectors, which is a critical process for cells to receive, interpret and respond to extracellular signals. Go protein belongs to the pertussis toxin-sensitive Gi/Go subfamily of G proteins. A number of G-protein-coupled receptors transmit stimuli to intercellular effectors through Go. Go regulates several cellular effectors, including ion channels, enzymes, and even small GTPases to modulate cellular function. This review summarizes some of the advances in Go research and proposes areas to be further addressed in exploring the functional role of Go. Copyright (C) 2009 S. Karger AG, Basel
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available