Journal
NEUROSIGNALS
Volume 16, Issue 2-3, Pages 124-139Publisher
KARGER
DOI: 10.1159/000111558
Keywords
ceramide; neural progenitors; sphingosine-1-phosphate; FTY720; stem cell therapy; myelination
Funding
- NINDS NIH HHS [R01NS046835] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS046835] Funding Source: NIH RePORTER
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Ceramide and its derivative sphingosine-1-phosphate (S1P) are important signaling sphingolipids for neural stem cell apoptosis and differentiation. Most recently, our group has shown that novel ceramide analogs can be used to eliminate teratoma (stem cell tumor)-forming cells from a neural stem cell graft. In new studies, we found that S1P promotes survival of specific neural precursor cells that undergo differentiation to cells expressing oligodendroglial markers. Our studies suggest that a combination of novel ceramide and S1P analogs eliminates tumor-forming stem cells and at the same time, triggers oligodendroglial differentiation. This review discusses recent studies on the function of ceramide and S1P for the regulation of apoptosis, differentiation, and polarity in stem cells. We will also discuss results from studies in our laboratory on the use of sphingolipids in stem cell therapy. Copyright (c) 2008 S. Karger AG, Basel.
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