Fibroblast Growth Factor Homologous Factors: New Roles in Neuronal Health and Disease

Fibroblast growth factor homologous factors (FHFs) are a noncanonical subset of intracellular fibroblast growth factors that have been implicated in a variety of neurobiological processes and in disease. They are most prominently regulators of voltage-gated Na+ channels (Na(V)s). In this review, we discuss new insights into how FHFs modulate Na(V)s. This is followed by a summary of a growing body of evidence that FHFs operate in much broader fashion. Finally, we highlight unknown aspects of FHF function as areas of future interest.