Journal
NEUROSCIENTIST
Volume 22, Issue 1, Pages 19-25Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858414562217
Keywords
fibroblast growth factors; fibroblast growth factor homologous factors; voltage-gated sodium channels; neuron cell biology; spinocerebellar ataxia
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Funding
- National Institutes of Health [R01 HL112918, R01 HL122967, R01 HL071165]
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Fibroblast growth factor homologous factors (FHFs) are a noncanonical subset of intracellular fibroblast growth factors that have been implicated in a variety of neurobiological processes and in disease. They are most prominently regulators of voltage-gated Na+ channels (Na(V)s). In this review, we discuss new insights into how FHFs modulate Na(V)s. This is followed by a summary of a growing body of evidence that FHFs operate in much broader fashion. Finally, we highlight unknown aspects of FHF function as areas of future interest.
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