Journal
NEUROSCIENTIST
Volume 18, Issue 4, Pages 373-385Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858411410354
Keywords
anterior cingulate; anterior insula; frontotemporal dementia; functional connectivity; von Economo neuron
Categories
Funding
- National Institutes on Aging [AG027086, AG03006, AG033017, AG023501]
- James S. McDonnell Foundation
- Larry L. Hillblom Foundation
- Consortium for Frontotemporal Dementia Research
- John Douglas French Alzheimer Foundation
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The behavioral variant of frontotemporal dementia (bvFTD) slowly undermines emotion, social behavior, personal conduct, and decision making. These deficits occur in concert with focal neurodegeneration that can be quantified with modern structural and functional imaging and neuropathological methods. As a result, studies of bvFTD have helped to clarify brain structures, networks, and neurons that prove critical for normal social-emotional functioning. In this article, the authors review the evolving bvFTD literature and propose a simple, testable network-based working model for understanding bvFTD.
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