Journal
NEUROSCIENTIST
Volume 14, Issue 6, Pages 609-625Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858408322675
Keywords
Presynaptic NMDA receptors; Timing-dependent long-term depression; Spike timing-dependent plasticity; Cortex; Development
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Funding
- NIGMS [NRSA F31GM080162-01]
- HHMI Predoctoral Fellowship
- NINDS [R01 NS046652-05]
- Whitehall Foundation
- NEI [RO1 EY018323-01]
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Many aspects of synaptic development, plasticity, and neurotransmission are critically influenced by NMDA-type glutamate receptors (NMDARs). Moreover, dysfunction of NMDARs has been implicated in a broad array of neurological disorders, including schizophrenia, stroke, epilepsy, and neuropathic pain. Classically, NMDARs were thought to be exclusively postsynaptic. However, substantial evidence in the past 10 years demonstrates that NMDARs also exist presynaptically and that presynaptic NMDA receptors (preNMDARs) modulate synapse function and have critical roles in plasticity at many synapses. Here the authors review current knowledge of the role of preNMDARs in synaptic transmission and plasticity, focusing on the neocortex. They discuss the prevalence, function, and development of these receptors, and their potential modification by experience and in brain pathology. NEUROSCIENTIST 14(6): 609-625, 2008. DOI: 10.1177/1073858408322675
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