Journal
NEUROSCIENCE RESEARCH
Volume 138, Issue -, Pages 26-32Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2018.09.012
Keywords
Ganglionic eminence; MGE and CGE; Migration; Transcription factor; Fate mapping; Clonal analysis; Single cell RNA sequencing
Categories
Funding
- Mochida Memorial Foundation for Medical and Pharmaceutical Research
- Cell Science Research Foundation
- Takeda Science Foundation
- Brain Science Foundation
- [17H05775]
- [17K07102]
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GABAergic interneurons in the neocortex play pivotal roles in the feedforward and feedback inhibition that control higher order information processing and thus, malfunction in the inhibitory circuits often leads to neurodevelopmental disorders. Very interestingly, a large diversity of morphology, synaptic targeting specificity, electrophysiological properties and molecular expression profiles are found in cortical interneurons, which originate within the distantly located embryonic ganglionic eminences. Here, I will review the still ongoing effort to understand the developmental trajectories of GABAergic cortical interneuron subtypes. (C) 2018 Elsevier B.V. and Japan Neuroscience Society. All rights reserved.
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