Journal
NEUROSCIENCE RESEARCH
Volume 88, Issue -, Pages 67-73Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2014.08.007
Keywords
Stroke; Cell therapy; Sensorimotor recovery; Middle-age
Categories
Funding
- Rio de Janeiro State Foundation for Research Support (FAPERJ)
- Institutional Program of Scientific Initiation Scholarships of UENF/National Council for Scientific and Technological Development (PIBIC-UENF/CNPq)
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Stroke is a disease of the elderly. However, most of the preclinical studies about the treatment of stroke with bone marrow-derived cells have used young animals. Here, it was assessed whether the sensorimotor recovery promoted by the treatment of the brain ischemia with the bone marrow mononuclear cells (BMMCs) is influenced by age and/or gender. Unilateral cortical ischemia by thermocoagulation was made in the primary motor and sensorimotor cortices in young and middle-aged rats of both genders. Twenty four hours after ischemia, animals received intravenous injection of BMMCs or vehicle. Each combination of age and gender received BMMCs from donor with the same combination. Survival rate and ischemic lesion size were quantified. Sensorimotor recovery was evaluated by the cylinder and adhesive tests. The results showed that the treatment with BMMCs resulted in sensorimotor recovery of both young and middle-aged ischemic rats. No important effect of gender was found, but age was a significant factor. Middle-aged animals had increased mortality and lesion sizes. In the adhesive test, middle-aged animals had lower BMMCs-induced sensorimotor recovery. The results suggest that the treatment of stroke with the BMMCs should be beneficial for males and females in the elderly. (C) 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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