Journal
NEUROSCIENCE RESEARCH
Volume 88, Issue -, Pages 84-87Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2014.07.010
Keywords
Zebrafish; Spinal cord regeneration; Sox2; Cell proliferation
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Funding
- JSPS KAKENHI [25890007, 25640008]
- MEXT/JST Tenure Track Promotion Program
- Grants-in-Aid for Scientific Research [25640008, 25890007, 25462753] Funding Source: KAKEN
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The sex-determining region Y-box 2 (Sox2) is related not only to pluripotency, but also to cell proliferation. Zebrafish can regain their motor function after spinal cord injury (SCI). Following SCI, new motor neurons are produced from proliferating ependymal cells. Here, we investigated the expression and function of Sox2 after SCI in zebrafish. Sox2 was upregulated as early as 1 day post-lesion (dpl) in ependymal cells, which was followed by cell proliferation. Sox2 knockdown significantly decreased the number of proliferating cells at 5 dpl. The results of this study suggest a role of Sox2 as one of the proliferation initiators in ependymal cells after SCI. (C) 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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