Journal
NEUROSCIENCE RESEARCH
Volume 77, Issue 4, Pages 247-250Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2013.09.010
Keywords
Olfactory cells; Lymphoblasts; Stem cells; Gene expression profile; Schizophrenia; Bipolar disorder
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Funding
- USPHS [MH-084018, MH-094268]
- Silvo O. Conte Center [MH069853, MH-085226, MH-088753, MH-092443, MH-096208, K99MH-093458]
- Stanley Foundation
- RUSK Foundation
- S-R Foundation
- NARSAD
- Japanese Ministry of Education, Culture, Sports, Science and Technology
- Maryland Stem Cell Research Fund
- Hammerschlag family
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Human olfactory cells obtained by rapid nasal biopsy have been suggested to be a good surrogate system to address brain disease-associated molecular changes. Nonetheless, whether use of this experimental strategy is justified remains unclear. Here we compared expression profiles of olfactory cells systematically with those from the brain tissues and other cells. Principal component analysis indicated that the expression profiles of olfactory cells are very different from those of blood cells, but are closer to those of stem cells, in particular mesenchymal stem cells, that can be differentiated into the cells of the central nervous system. (c) 2013 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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