Journal
NEUROSCIENCE RESEARCH
Volume 73, Issue 1, Pages 1-7Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2012.02.012
Keywords
Endocytosis; Calcium; Calyx of Held; Synaptic vesicles; Hippocampal neurons; Calmodulin; Calcineurin; Synaptotagmin
Categories
Funding
- Japan Neuroscience Society
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Action potentials, when arriving at presynaptic terminals, elicit Ca2+ influx through voltage-gated Ca2+ channels. Intracellular [Ca2+] elevation around the channels subsequently triggers synaptic vesicle exocytosis and also induces various protein reactions that regulate vesicle endocytosis and recycling to provide for long-term sustainability of synaptic transmission. Recent studies using membrane capacitance measurements, as well as high-resolution optical imaging, have revealed that the dominant type of synaptic vesicle endocytosis at central nervous system synapses is mediated by clathrin and dynamin. Furthermore. Ca2+-dependent mechanisms regulating endocytosis may operate in different ways depending on the distance from Ca2+ channels: (1) intracellular Ca2+ in the immediate vicinity of a Ca2+ channel plays an essential role in triggering endocytosis, and (2) intracellular Ca2+ traveling far from the channels has a modulatory effect on endocytosis at the periactive zone. Here. I integrate the latest progress in this field to propose a compartmental model for regulation of vesicle endocytosis at synapses and discuss the possible roles of presynaptic Ca2+-binding proteins including calmodulin, calcineurin and synaptotagmin. (c) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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