Journal
NEUROSCIENCE RESEARCH
Volume 73, Issue 3, Pages 263-268Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2012.04.005
Keywords
Neural stem cells; Embryonic stem cells; X-irradiation; Capabilities for proliferation and differentiation
Categories
Funding
- JCIA [10J06233, 20500339]
- Tokyo Metropolitan University
- Grants-in-Aid for Scientific Research [10J06233] Funding Source: KAKEN
Ask authors/readers for more resources
Exposure of the fetal brain to ionizing radiation causes congenital brain abnormalities. Normal brain formation requires regionally and temporally appropriate proliferation and differentiation of neural stem cells (NSCs) into neurons and glia. Here, we investigated the effects of X-irradiation on proliferating homogenous NSCs prepared from mouse ES cells. Cells irradiated with X-rays at a dose of 1 Gy maintained the capabilities for proliferation and differentiation but stopped proliferation temporarily. In contrast, the cells ceased proliferation following irradiation at a dose of >5 Gy. These results suggest that irradiation of the fetal brain at relatively low doses may cause congenital brain abnormalities as with relatively high doses. (C) 2012 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available