Journal
NEUROSCIENCE RESEARCH
Volume 70, Issue 1, Pages 16-23Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2011.03.005
Keywords
Presynaptic terminal; Ca2+; Calmodulin; Metabotropic glutamate receptor; Mitochondria; ATP
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Funding
- Grants-in-Aid for Scientific Research [23650169] Funding Source: KAKEN
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Neuronal firing activity controls protein function and dynamically remodels synaptic efficacy. Exocytosis is triggered and regulated by Ca2+, which enters through voltage-gated Ca2+ (CaV) channels and diffuses into the presynaptic terminal accompanying action potential firings. Residual Ca2+ is sensed by Ca2+-binding proteins; among other potential actions, it mediates time- and space-dependent synaptic facilitation and depression via effects on Ca(v)2 channel gating and vesicle replenishment in the readily releasable pool (RRP). Mitochondria are also associated with short-term synaptic plasticity due to a sufficient ATP supply for vesicle mobilization into the RRP. Mitochondria-deficient synapses with impaired anterograde transport of mitochondria in neuronal processes show defects in presynaptic short-term plasticity. (C) 2011 Elsevier Ireland Ltd and the japan Neuroscience Society. All rights reserved.
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