Journal
NEUROSCIENCE RESEARCH
Volume 67, Issue 1, Pages 59-64Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2010.01.004
Keywords
Mexiletine; Motor evoked potentials; Gliotoxin; Demyelination; Spinal cord; Rat
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Funding
- KICOS
- MEST of Korea
- Ministry of Education, Science, and Technology [R11-2005-014]
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This study was conducted to whether the administration of mexiletine, a Na+ channel blocker, impacts the recovery from demyelination. Under anesthesia, 0.1% ethidium bromide was injected into the dorsal funiculus (T3), followed by a mexiletine or saline treatment Motor evoked potential (MEP) recordings and luxol fast blue stainings were performed at one, seven, 14, and 21 days post-operatively. Conduction was delayed during demyelination, but the mexiletine-injected group demonstrated shortened latencies and reductions in the demyelination area when compared to the control. These results suggest that systemic mexiletine plays a positive role in protecting neural tissues from demyelination. (C) 2010 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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