Journal
NEUROSCIENCE RESEARCH
Volume 66, Issue 2, Pages 223-227Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2009.10.007
Keywords
Human circadian rhythm; Human biological clock; Mononuclear cells; Clock genes; Self-sustained circadian rhythm; Luciferase
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology
- Grants-in-Aid for Scientific Research [21390064] Funding Source: KAKEN
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Disturbed circadian rhythmicity is associated with human diseases such as sleep and mood disorders. However, study of human endogenous circadian rhythm is laborious and time-consuming, which hampers the elucidation of diseases. It has been reported that peripheral tissues exhibit circadian rhythmicity as the suprachiasmatic nucleus-the center of the biological clock. We tried to study human circadian rhythm using cultured peripheral blood mononuclear cells (PBMCs) obtained from a single collection of venous blood. Activated human PBMCs showed self-sustained circadian rhythm of clock gene expression, which indicates that they are useful for investigating human endogenous circadian rhythm. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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