Journal
NEUROSCIENCE RESEARCH
Volume 64, Issue 3, Pages 330-334Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2009.04.004
Keywords
Caloric restriction; Astrocytes; Glutamate uptake; Glutamine synthetase; S100B
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Funda do de Amparo Pesquisa do Rio Grande do Sul (FAPERGS)
- Coordena do de Aperfei oamento de Pessoal de Nivel Superior (CAPES)
- FINEP/Rede [IBN 01.06.0842-00]
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Recent studies indicate that caloric restriction (CR) protects the central nervous system from several pathological conditions. The impairment of astroglial cell function, including glutamate uptake, glutamine synthetase (GS) activity and S100B secretion, may contribute to the progression of neurological disorders. The present study aimed to evaluate hippocampal astrocytic changes in response to CR diet, measuring astroglial parameters, such as glutamate uptake, GS activity and the immunocontent of GFAP and S100B. Blood biochemical parameters were also analyzed. Rats (60-day old) were fed ad libitum or on CR diets for 12 weeks. CR-fed rats showed approximately 16% less body weight gain than control rats. The CR diet was able to induce a significant increase in glutamate uptake (23%) and in GS activity (26%). There were no statistically significant differences in the immunocontent of either GFAP or S100B. In summary, the present study indicates that CR also modulates astrocyte functions by increasing glutamate uptake and GS activity, suggesting that CR might exert its neuroprotective effects against brain illness by modulation of astrocytic functions. (c) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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