Journal
NEUROSCIENCE RESEARCH
Volume 62, Issue 4, Pages 236-239Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2008.08.010
Keywords
Antisense RNA; RNA interference; Transcriptome; Synaptic plasticity
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Funding
- NIH [MH81099, LM07292]
- National Library of Medicine
- National Institute of Mental Health
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Natural antisense transcripts and overlapping sense transcripts are expressed in a variety of tissues, including adult mouse brain. Here we show that a subset of mRNA-like sense-antisense transcript pairs are co-expressed within synaptoneurosomes of adult mouse forebrain, a subcellular fraction that is enriched in pinched-off dendritic spines of pyramidal neurons. Several of these pairs involve mRNAs that have been implicated in synaptic functions and in Alzheimer disease pathways. This study provides evidence that a new class of noncoding RNAs (natural antisense transcripts) are expressed near synapses, and encourages further studies of their roles in neuronal function. (C) 2008 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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