Journal
NEUROSCIENCE LETTERS
Volume 578, Issue -, Pages 133-138Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2014.06.052
Keywords
Pericytes; Tumor necrosis factor-alpha; Microglia; Neurovascular unit; Brain inflammation; Blood-brain barrier
Categories
Funding
- Japan Society for the Promotion of Science [25460236, 23790113, 24790102]
- Central Research Institute of Fukuoka University [141104, 122504, 117113, 136005]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [23790113, 25460236, 24790102] Funding Source: KAKEN
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Brain pericytes are involved in neurovascular dysfunction, neurodegeneration and/or neuroinflammation. In the present study, we focused on the proinflammatory properties of brain pericytes to understand their participation in the induction of inflammation at the neurovascular unit (NVU). The NVU comprises different cell types, namely, brain microvascular endothelial cells, pericytes, astrocytes and microglia. Among these, we found pericytes to be the most sensitive to tumor necrosis factor (TNF)-alpha, possessing a unique cytokine and chemokine release profile. This was characterized by marked release of interleukin (IL)-6 and macrophage inflammatory protein-1 alpha. Furthermore, TNF-alpha-stimulated pericytes induced expression of inducible nitric oxide synthase and IL-1 beta mRNAs, as an index of BV-2 microglial cell activation state, to the highest levels. Based on these findings, the possibility that brain pericytes act specifically as TNF-alpha-sensitive cells and as effectors of TNF-alpha through the release of proinflammatory factors, and that, as such, they have a role in inducing brain inflammation, should be considered. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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