Journal
NEUROSCIENCE LETTERS
Volume 560, Issue -, Pages 103-106Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2013.12.024
Keywords
Methamphetamine; Behavioral sensitization; Single-dose injection; Repeated-dose injection
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Funding
- National Nature Science Foundation of China [30870894]
- National Basic Research Program of China [2009CB522000]
- National Key Technology R&D Program of China [2011BAKO4B08]
- Key Research Items of Ministry of Public Security [2009ZDYJHLJT003]
- National Institute on Drug Abuse of the National Institutes of Health [R01DA034806, R21DA033426]
- National Natural Science Foundation of China [81373390]
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Repeated exposure to drugs of abuse produces a persistent behavioral sensitization to stimulants, which is often used to study drug-associated behavioral plasticity. Interestingly, even a single exposure to some drugs of abuse is sufficient to elicit long-lasting behavioral sensitization. However, few studies have directly compared the magnitude of sensitization between single versus repeated drug treatments. This study examined the magnitude and duration of single methamphetamine (METH) injection-induced behavioral sensitization and compared it to the more typical repeated drug injection-induced sensitization in mice. Different groups of mice were injected with METH (0.5, 1.0, 2.0 mg/kg, i.p.) only once or daily for 7 consecutive days. A challenge dose of METH (1.0 mg/kg, i.p.) was tested 7 days later. The time-course of a single METH injection-induced behavioral sensitization was assessed where METH (2.0 mg/kg, i.p.) was injected and a challenge dose of METH (1.0 mg/kg, i.p.) was tested after different drug-free periods. Single METH injection produced similar magnitude of behavioral sensitization as compared to repeated injection. Such a sensitized locomotor response peaked 8 days after METH injection and lasted for at least 21 days. This long lasting behavioral alteration induced by single METH injection suggests the value of future studies to explore the underlying neural mechanisms, particularly in comparison to those underlying repeated METH-induced sensitization. Published by Elsevier Ireland Ltd.
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