Journal
NEUROSCIENCE LETTERS
Volume 579, Issue -, Pages 177-182Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2014.07.039
Keywords
cFos; AVP; VIP; Circadian rhythm; Cold exposure
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology
- MEXT KIBANKEISEI
- Strategic Research Platforms for Private University
- Hayashi Memorial Foundation
- [20390066]
- [24800047]
- Grants-in-Aid for Scientific Research [25280101] Funding Source: KAKEN
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Cold defense mechanisms in mice are attenuated in the light phase during fasting, resulting in hypothermia. The present study examined whether specific neurons and areas in the SCN are related to the response. Mice were fasted over 47 h or remained fed, during which they were placed at 20 or 27 degrees C for 3 h in the light or dark phases. Body temperature (T-b) was monitored. After the exposure, immunoreactive (IR) cells of cFos, arginine vasopressin (AVP), and vasoactive intestinal polypeptide (VIP) in the SCN were assessed. T-b at 20 degrees C during fasting was lower in the light phase than in the dark phase. Both AVP/cFos-IR and VIP/cFos-IR cells increased when mice were at 20 degrees C during fasting in the light phase. Such increase was observed in the central part of the SCN. These responses in the SCN may be related to the hypothermia in the light phase. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
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