Journal
NEUROSCIENCE LETTERS
Volume 544, Issue -, Pages 105-109Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2013.03.054
Keywords
Essential oil; Antidepressant-like; Eugenia uniflora
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In this work we evaluated antidepressant-like effect of E. uniflora leaves EO employing the tail suspension test. The involvement of serotonergic and adrenergic systems was appraised. EO was administered by oral route (p.o.) in mice and the doses of 10 and 50 mg/kg exhibited antidepressant-like action in the TST. The effect of EO (10 mg/kg) was prevented by the pretreatment of mice with ketanserin (5 mg/kg, intraperitoneal), prazosin (0.1 mg/kg, i.p.) and yohimbine (0.1 mg/kg, i.p.). In addition, further analysis of the in vitro antioxidant effect of the EO was made against lipid oxidation. The results revealed that EO has a potent antioxidant activity and therapeutic potential for the development of phytomedicines with antidepressant and antioxidant properties. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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