Journal
NEUROSCIENCE LETTERS
Volume 541, Issue -, Pages 58-62Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2013.02.007
Keywords
Dose-dependent effect; Isoflurane; Cerebral blood flow (CBF); Auto-regulation; Non-human primate; Arterial spin labeling (ASL)
Categories
Funding
- National Center for Research Resources [P51RR000165]
- Office of Research Infrastructure Programs/OD [P51OD011132]
- National Institutes of Health, National Center for Research Resources [UL1 RR025008]
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [UL1TR000454] Funding Source: NIH RePORTER
- NATIONAL CENTER FOR RESEARCH RESOURCES [P51RR000165, UL1RR025008] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [P51OD011132] Funding Source: NIH RePORTER
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The dose-dependent effect of isoflurane on regional CBF of cortical and subcortical structures in anesthetized macaque monkeys was investigated with the Continuous ASL MRI technique. High concentration of isoflurane resulted in global CBF increase and blood pressure decrease. Evident CBF change was observed in the subcortical structures. Specifically, CBF in thalamus and cerebellum was increased about 39% and 55% when isoflurane concentration was changed from 0.75% to 1.5%, respectively. Also, those regional CBF changes correlated linearly with isoflurane inspiratory concentrations, indicating impaired CBF autoregulation in these structures. In contrast, no obvious CBF changes were observed in anterior cingulated cortex, motor cortex, medial prefrontal cortex, and caudate. The results demonstrate that, under the 0.75-1.5% isoflurane maintenance doses, the CBF auto-regulation is well preserved in the cerebral cortical regions and caudate, but impaired in thalamus and cerebellum, indicating disturbed CBF-metabolism coupling and functional response in specific subcortical regions of anesthetized macaque monkeys. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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