Journal
NEUROSCIENCE LETTERS
Volume 541, Issue -, Pages 190-192Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2013.02.048
Keywords
Parkinson's disease; rs6812193 polymorphism; SCARB2 gene
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In a recent web based genome-wide association study (GWA) the rs6812193 polymorphism was identified as a new risk factor for Parkinson's disease (PD). The purpose of our study was to examine the association of the rs6812193 polymorphism with Parkinson's disease (PD) in case-control association study of Greek individuals. We studied a total of 343 individuals, 210 Greek patients with sporadic PD and 133 control subjects, using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. We found no differences in genotype or allele frequencies between PD patients and controls (P=0.795 and P=0.892, respectively), suggesting that the rs6812193 polymorphism does not increase susceptibility to PD in the Greek population. Additional studies further investigating the association of the rs6812193 polymorphism with PD are needed in order to clarify the role of this polymorphism in different ethnicities. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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