Journal
NEUROSCIENCE LETTERS
Volume 520, Issue 2, Pages 197-203Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2012.05.001
Keywords
Chronic pain; Functional magnetic resonance imaging; Network; Diffusion tensor imaging; Neuroplasticity; Learning
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Funding
- NINDS NIH HHS [R01 NS035115, R01 NS042660, R01 NS057704] Funding Source: Medline
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We briefly summarize recent advances regarding brain functional representation of chronic pain, reorganization of resting state brain activity, and of brain anatomy with chronic pain. Based on these observations and recent theoretical advances regarding network architecture properties, we develop a general concept of the dynamic interplay between anatomy and function as the brain progresses into persistent pain, and outline the role of mesolimbic learning mechanisms that are likely involved in maintenance of chronic pain. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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