Journal
NEUROSCIENCE LETTERS
Volume 528, Issue 2, Pages 190-195Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2012.08.079
Keywords
Heptamethoxyflavone; Global cerebral ischemia; BDNF; Neurogenesis; ERK1/2; CREB
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Funding
- Japan Society for the Promotion of Science [23700941]
- Science Research Promotion Fund of The Promotion and Mutual Aid Corporation for Private Schools of Japan
- Research Promotion Fund of Ehime Industrial Promotion Foundation
- Grants-in-Aid for Scientific Research [23700941] Funding Source: KAKEN
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In the present study using a transient global ischemia mouse model, we showed that (1) a citrus flavonoid 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF) induced the phosphorylation of extracellular signal-regulated kinases 1/2 (ERK1/2) and cAMP response element-binding protein (CREB) in the hippocampus after ischemia: (2) HMF increased the expression of brain-derived neurotrophic factor (BDNF), a representative neurotrophic factor in the central nervous system, in the hippocampal dentate gyrus, and most BDNF-positive cells were also stained with anti-glial fibrillary acidic protein (one of the major intermediate filament proteins of mature astrocytes) and (3) HMF increased doublecortin positive neuronal precursor cells in the dentate gyrus subventricular zone or subgranular zone. These results suggest that HMF has the ability to induce BDNF production in astrocytes and enhance neurogenesis after brain ischemia, which may be mediated by activation of ERK1/2 and CREB. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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