Journal
NEUROSCIENCE LETTERS
Volume 528, Issue 1, Pages 27-30Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2012.08.081
Keywords
Crocins; mCPP; Self-grooming; Obsessive-compulsive disorder; Rat
Categories
Funding
- European Union
- Greek National Funds through the Research Funding Program Heracleitus II [4190.01.17]
- Research Committee of the University of Thessaly [3219]
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Crocins are among the active components of the plant Crocus Sativus L C. Sativus L and its constituents were effective in different models of psychiatric disorders including anxiety and depression. Obsessive-compulsive disorder (OCD) is a common psychiatric disorder defined by the presence of obsessive thoughts and repetitive compulsive actions. The non selective serotonin (5-HT) receptor agonist mCPP is known to induce OCD-like behavior (excessive self-grooming) in rodents and exacerbate symptoms in patients with OCD. The present study investigated whether or not crocins were able to counteract excessive self-grooming induced by mCPP (0.6 mg/kg, i.p.) in rats. Crocins (30 and 50 mg/kg, i.p.) attenuated mCPP-induced excessive self-grooming. The present results also indicate that these effects of crocins on an animal model of OCD cannot be attributed to changes in locomotor activity. Our findings suggest that the active constituents of C. Sativus L crocins might play a role in compulsive behavior and support a functional interaction between crocins and the serotonergic system. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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