Journal
NEUROSCIENCE LETTERS
Volume 509, Issue 2, Pages 96-100Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.12.047
Keywords
Lateral superior olive (LSO); Medial nucleus of trapezoid body (MNTB); Endocannabinoids; Cannabinoid receptors (CB1R)
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Funding
- National Institute on Deafness and Other Communication Disorders [R01 04199]
- [R01 04199-11S1]
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The organization of developing auditory circuits depends on the elimination of aberrant connections and strengthening of appropriate ones. Endocannabinoid mediated plasticity is a proposed mechanism for this refinement. Here we investigated for the anatomical presence of cannabinoid receptors (CB1R) in the lateral superior olive (LSO) and medial nucleus of the trapezoid body (MNTB) of developing rats. We found that CB1R is present within the LSO and that it colocalized with vesicular glutamate transporter (VGLUT3), a presynaptic marker for MTNB terminals. Both before (P5) and around hearing onset (P12). the expression levels of CB1R were higher in the lateral limb of the LSO than in the medial limb. These results suggest that endocannabinoid signaling can modulate the strength of the developing MNTB-LSO synapse. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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