Journal
NEUROSCIENCE LETTERS
Volume 509, Issue 2, Pages 69-71Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.12.029
Keywords
beta-Lactam antibiotic; Ceftriaxone; GLT-1; Opioid; Allodynia; Hyperalgesia
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Funding
- NIH [RO1 HL098141]
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The glutamate transporter GLT-1 is primarily responsible for glutamate clearance in the spinal cord. beta-Lactam antibiotics have been shown to attenuate neuropathic pain behaviors by promoting GLT-1 expression and function in the CNS. The present study tested the hypothesis that ceftriaxone, a prototype beta-lactam antibiotic, can prevent the development of opioid-induced hyperalgesia (OIH) in mice. Repeated morphine administration produced mechanical allodynia and thermal hyperalgesia, signs of OIH, and reduced spinal GLT-1 expression in mice. Ceftriaxone (200 mg/kg/d, i.p., for 7 d) inhibited OIH. Correlating with the behavioral effects, ceftriaxone reversed downregulation of GLT-1 expression that was induced by OIH. These results suggest that ceftriaxone inhibited the development of OIH by up-regulating spinal GLT-1 expression. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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