Journal
NEUROSCIENCE LETTERS
Volume 506, Issue 1, Pages 155-159Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.10.071
Keywords
Aging; Alzheimer's disease; Eyeblink conditioning; Hippocampus; Trace conditioning
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Funding
- Takeda Science Foundation
- Smoking Research Foundation
- [20790084]
- Grants-in-Aid for Scientific Research [24590133] Funding Source: KAKEN
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Eyeblink conditioning has been used for assessing cognitive performance in cases of human neurodegenerative diseases including Alzheimer's disease (AD). Here, we tested and compared the delay and long-trace interval (TI = 500 ms) eyeblink conditionings in a Tg2576 mouse model of AD, at the age of 3, 6, and 12 months. Tg2576 mice exhibited significant impairment in trace conditioning at 6 months of age. In contrast, delay conditioning was not impaired in Tg2576 mice even at 12 months. These findings indicate that the long-TI eyeblink conditioning is more susceptible to age-related cognitive deterioration than delay conditioning in Tg2576 mice. The long-trace eyeblink conditioning could be a potential tool for detecting early cognitive deficits in AD mouse model. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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