Journal
NEUROSCIENCE LETTERS
Volume 524, Issue 1, Pages 10-15Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2012.06.063
Keywords
Parkinson's disease; Bicistronic; Neurturin; Tyrosine hydroxylase; Rhesus Macaque
Categories
Funding
- NSFC
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Neurturin (NTN) is a desired candidate therapeutic gene for PD treatment, however, only neuroprotective effect may not work for PD clinical remission due to nearly 50% of the dopaminergic neurons have died way when symptoms appear. In this study, we constructed a bicistronic adenovirus expressing both Neurturin and tyrosine hydroxylase (TH). We hypothesized that the expression of NTN could provide neuroprotection to dopaminergic neurons and stop progressive neurodegeneration, while TM enhanced the synthesis of dopamine and accelerated the recovery of Parkinsonism. The chimeric adenovirus have been prepared and assayed in vitro and delivered into the target nucleuses of PD Macaca Rhesus models by MRI based stereotaxic injection. The observation assessments and physiological results indicated that compared to the group treated with NTN only, instant behavior recovery was seen after bicistronic adenovirus infusion. Although both groups displayed neuroprotection of dopaminergic neurons finally, the addition of TH genuinely accelerated animal behavior recovery, which showed great potential for clinical application. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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