Journal
NEUROSCIENCE LETTERS
Volume 492, Issue 2, Pages 105-108Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.01.066
Keywords
Transcranial direct current stimulation; Cortical activation; Hand movement; Functional MRI
Categories
Funding
- Korean Government [2009-0064682]
- National Research Foundation of Korea [2009-0064682] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The aim of this study is to evaluate whether tDCS applied on the primary motor cortex (M1) in company with hand movements could enhance cortical activation, using functional MRI (fMRI). Twelve right-handed normal subjects were recruited. Real tDCS and sham tDCS with hand movements were applied during fMRI scanning. Subjects performed grasp-release hand movements at a metronome-guided frequency of 1 Hz, while direct current with 1.0 mA was delivered to the primary motor cortex. The averaged cortical map and the intensity index were compared between real tDCS with hand movements and sham tDCS with hand movements. Our result showed that cortical activation on the primary sensorimotor cortex was observed under both of two conditions; real tDCS with hand movements and sham tDCS with hand movements. Voxel count and peak intensity were 365.10 +/- 227.23 and 5.66 +/- 1.97, respectively, in the left primary sensorimotor cortex during real tDCS with right hand movements; in contrast, those were 182.20 +/- 117.88 and 4.12 +/- 0.88, respectively, during sham tDCS with right hand movements. Significant differences in voxel count and peak intensity were observed between real tDCS and sham tDCS (p < 0.05). We found that anodal tDCS application during motor task enhanced cortical activation on the underlying targeted motor cortex, compared with the same motor task without tDCS. Therefore, it seemed that tDCS induced more cortical activity and modulated brain function when concurrently applied with motor task. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.
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