Journal
NEUROSCIENCE LETTERS
Volume 501, Issue 3, Pages 185-187Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.05.245
Keywords
Late-onset sporadic Parkinson disease; HLA-DRA; Rs3129882; Association
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Funding
- Fund of Hunan Province for Distinguished Young Scholar [09JJ1005]
- Sheng Hua Scholars Program
- Outstanding Youth Foundation of Central South University, China
- National Natural Science Foundation of China [30871351, 30870916]
- Ministry of Education of P.R. China [NCET-080563]
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of P.R. China
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Recently, the rs3129882 variant in intron 1 of HLA-DRA was found to be associated with late-onset sporadic Parkinson disease (PD) in Americans of European ancestry. To evaluate whether the same variant is related to PD in Chinese population, we investigated late-onset sporadic PD patients of Chinese Han ethanicity in Mainland China. We found significant difference in genotypic and allele distribution between patients and control subjects (chi(2)=6.446, p=0.040 for genotypic distribution; chi(2)=5.762, p=0.016 for allele distribution), suggesting this variant is associated with late-onset sporadic PD in Chinese Han population. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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