Journal
NEUROSCIENCE LETTERS
Volume 495, Issue 3, Pages 201-204Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.03.065
Keywords
Akt; Mammalian target or rapamycin; Methylcobalamin; Neurite outgrowth
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Funding
- General Insurance Association of Japan
- Grants-in-Aid for Scientific Research [21659353] Funding Source: KAKEN
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Methylcobalamin (MeCbl), a vitamin B12 analog, promotes neurite outgrowth by activating Akt in neurons. However, Akt is involved in many cellular functions, and the downstream signal of Akt that promotes neurite outgrowth in neurons in the presence of MeCbl remains obscure. Mammalian target of rapamycin (mTOR) is a serine/threonine protein kinase that regulates multiple cellular functions including neurite outgrowth. mTOR is regarded as important for the regeneration of injured nerves. In this study, we examined the relationship between MeCbl and mTOR activity and found that MeCbl increases mTOR activity via the activation of Akt and promotes neurite outgrowth in cerebellar granule neurons via the activation of mTOR. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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