Journal
NEUROSCIENCE LETTERS
Volume 499, Issue 1, Pages 9-13Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.05.019
Keywords
Amyotrophic lateral Sclerosis; Neurogenesis; Frontotemporal lobar degeneration; Motor neuron disease; Subventricular zone
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Funding
- Carlos III Health Institute
- Ministry of Health of the Generalitat Valenciana
- Foundation of the Valencian Community Prince Felipe Research Centre (PROMETEO)
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Investigate how the subventricular proliferation and organisation is modified in a patient with FTLD-ALS. We studied the subventricular zone (SVZ) of a patient with FTLD-ALS immunohistochemical and histologically. We found an increase of Ki-67 positive cells and neuroblast in the subventricular zone, suggesting an activation of proliferating activity in response to FTD-ALS. This proliferation can act as a compensatory mechanism for rapid neuronal death and its modulation could provide a new therapeutic pathway in ALS. These results suggest a modification of neurogenesis in FTD-ALS. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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