Journal
NEUROSCIENCE LETTERS
Volume 496, Issue 1, Pages 1-4Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.03.073
Keywords
Overepression; Shadoo; Mouse model; Incubation times; Scrapie pathogenesis
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Funding
- Natural Science Foundation of China [30972197, 31072148]
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Shadoo is a glycoprotein expressed in the adult brain that is an interacting protein of prion protein: however, its function remains to be determined. To elucidate its role in prion pathogenesis, we generated transgenic mice overexpressing wild-type (wt) Shadoo driven by the murine PrP promoter. Expression of the murine Sprn transgene significantly increased brain Shadoo protein levels in all three mouse lines generated. Following infection with mouse-adapted scrapie strain 22L, all transgenic mice tested exhibited characteristics of scrapie disease. Importantly, there was no correlation between the expression level or incubation time of Shadoo with disease phenotype. We therefore conclude that Shadoo has little or no influence on the outcome of transmissible spongiform encephalopathy (TSE) disease in transgenic mice. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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