Journal
NEUROSCIENCE LETTERS
Volume 497, Issue 3, Pages 155-162Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2011.02.032
Keywords
Epileptogenesis; Febrile seizures; Inflammation; Gene expression; Biomarkers
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Funding
- NIH [R37NS35439, T32NS045540, NS35439-S1 (ARRA)]
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Epidemiological and recent prospective analyses of long febrile seizures (FS) and febrile status epilepticus (FSE) support the idea that in some children, such seizures can provoke temporal lobe epilepsy (TLE). Because of the high prevalence of these seizures, if epilepsy was to arise as their direct consequence, this would constitute a significant clinical problem. Here we discuss these issues, and describe the use of animal models of prolonged FS and of FSE to address the following questions: Are long FS epileptogenic? What governs this epileptogenesis? What are the mechanisms? Are there any predictive biomarkers of the epileptogenic process, and can these be utilized, together with information about the mechanisms of epileptogenesis, for eventual prevention of the TLE that results from long FS and FSE. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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