Journal
NEUROSCIENCE LETTERS
Volume 486, Issue 1, Pages 38-42Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2010.09.040
Keywords
Exendin-4; Neurogenesis; Cell proliferation; Neuroblast differentiation; Subgranular zone
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Funding
- Ministry of Education, Science and Technology [2009-0084089]
- Ministry of Education, Science and Technology, the Republic of Korea [2009K001290]
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Exendin-4 isolated from Heloderma suspectum venom acts via glucagon-like peptide 1 (GLP-1) receptor and has clinically been used in the type 2 diabetes. In this study, we investigated the effects of exendin-4 on cell proliferation and neuroblast differentiation in the subgranular zone (SGZ) of the dentate gyrus in mice. Exendin-4 was treated intraperitoneally to male ICR mice twice a day for 21 days. The exendin-4-treated group showed a significantly higher number of Ki67- (1.51-fold), doublecortin (DCX)- (2.5-fold) and 5-bromo-2'-deoxyuridine (BrdU)+DCX- (2.46-fold) immunoreactive cells in the SGZ of the dentate gyrus compared to the control group. The results of this study showed that treatment with exendin-4 increased cell proliferation neuroblast differentiation in the SGZ of the dentate gyrus, suggesting that exendin-4 promotes structural plasticity in the dentate gyrus. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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