Journal
NEUROSCIENCE LETTERS
Volume 481, Issue 2, Pages 102-104Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2010.06.061
Keywords
Central pain; Norepinephrine; DSP-4; Locus coeruleus
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Funding
- Grants-in-Aid for Scientific Research [21390430] Funding Source: KAKEN
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Neuropathic pain models are classified as central and peripheral pain models. Although various peripheral neuropathic pain models are established, central pain models are based only on spinal cord injury. DSP-4 is a competitive inhibitor of norepinephrine uptake that selectively degenerates the locus coeruleus (LC)-noradrenergic neurons projection to the cerebral cortex and hippocampus. In the present study, we have tested whether lesion of LC-noradrenergic neurons by ip DSP-4 (0, 10, 30, 50 mg/kg, n = 7 each) could provide a new central neuropathic pain model in rats using a hot-plate and tail-flick tests. DSP-4 significantly reduced the hot-plate latency and norepinephrine contents especially in the coerulean regions. However, DSP-4 did not change tail-flick latency. There are significant correlations of the latency in the hot-plate test with norepinephrine contents in the cerebral cortex (r = 0.432, p = 0.022), the hippocampus (r = 0.465, p = 0.013) and the pons (r = 0.400, p = 0.035) but not with those in the hypothalamus and the spinal cord. As response to hot-plate and tail-flick implies supra-spinal process and spinal reflex, respectively, central neuropathic pain may be facilitated by DSP-4 depleting LC-noradrenergic neurons although the present data are preliminary. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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