Journal
NEUROSCIENCE LETTERS
Volume 481, Issue 2, Pages 97-101Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2010.06.060
Keywords
Epilepsy; Brain stimulation; Mediodorsal thalamic nucleus; Kindled seizures
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Funding
- National Natural Science Foundation of China [30725047, 30600194, 30572176]
- Zhejiang Provincial Natural Science Foundation of China [Z207289, Y206250]
- Zhejiang Province Healthy Excellent Youth Foundation [2009QN015]
- Ministry of Education, China [NCET-06-0511]
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Deep brain stimulation (DBS) is now emerging as a new option for treating intractable epilepsy. Cumulative studies suggest that the mediodorsal thalamic nucleus (MD) is involved in limbic seizure activity. This study aims to investigate whether DBS of the MD can protect against seizures induced by arnygdaloid kindling. We studied the effect of low-frequency stimulation (LFS, 1 Hz) or high-frequency stimulation (HFS, 100 Hz) in the MD on amygdaloid kindling seizures. During the kindling acquisition, DBS in the MD was daily administered immediately after the kindling stimulus or before the kindling stimulus (preemptive DBS). The effects of both post-treatment of DBS and preemptive DBS in the MD on the expression of amygdaloid kindling seizures were evaluated. We found the DBS or preemptive DBS in the MD, either LFS or HFS, did not significantly change the rate of amygdaloid kindling. Similarly, DBS or preemptive DBS in the MD did not significantly change any parameters representing the expression of amygdaloid kindling. Our study suggests that DBS in the MD may have no significant effect on limbic seizures. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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