Journal
NEUROSCIENCE LETTERS
Volume 468, Issue 1, Pages 75-79Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.10.068
Keywords
L-Serine; Rat; Social isolation; Locomotor activity
Categories
Funding
- Japan Society for the Promotion of Science
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L-Serine is considered a functional amino acid in the central nervous system, since intracerebroventricular injection of L-serine induced sedative and hypnotic effects in neonatal chicks exposed to acute stressful conditions. Accordingly, L-serine is a candidate anti-stress factor, but the effect of daily intake of L-serine on behavior of animals exposed to chronic stress has not been investigated. In the present study, we exposed rats to social isolation stress for 4 weeks, and home cage test and open field test were concluded to evaluate the effect of L-serine on behavior. To investigate L-serine supplementation modifies the brain L-serine and its metabolite contents, free amino acid contents were measured by a high performance liquid chromatography. L-Serine in the drinking water increased L-serine levels in some brain areas, but changes in its metabolites were almost negligible. L-serine decreased locomotor activity in rats exposed to a familiar environment. In addition, L-serine decreased exploratory behavior of isolated rats, even in a novel environment. Our results could suggest that daily intake Of L-serine can attenuate symptoms induced by chronic stress. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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