Journal
NEUROSCIENCE LETTERS
Volume 479, Issue 3, Pages 197-200Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2010.05.050
Keywords
Autism spectrum disorders (ASD); Single nucleotide polymorphisms (SNPs); Arginine vasopressin receptor 1A (AVPR1A); Family-base association study
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Funding
- Ministry of Health & Welfare, Republic of Korea [A080651]
- Korean Government (MOEHRD) [KRF-2008-331-C00226]
- Korea Health Promotion Institute [A080651] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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To determine the association between arginine vasopressin receptor 1A gene (AVPR1A)and autism spectrum disorders (ASDs), we examined 3 single nucleotide polymorphisms (SNPs), namely, rs7294536, rs3759292, and rs10877969, in the promoter region of AVPR1A by using a family-based association test (FBAT) in 151 Korean trios. Our results demonstrated a statistically significant association between autism and SNPs (additive model: rs7294536, chi(2)=9.328, df=2, P=0.002: rs10877969, chi(2)=11.529, df=2, P<0.001) as well as between autism and haplotype analysis (additive model: chi(2)=14.122, df=3,P=0.003). In addition, we found that ADI-R scores calculated by using a diagnostic algorithm for failure to develop peer relationships (A2) were higher in subjects having the AA genotype than in subjects having the AG and GG genotypes of rs7294536. Thus, our study provides evidence for a possible association between these SNPs and the phenotype of ASDs. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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