Journal
NEUROSCIENCE LETTERS
Volume 467, Issue 1, Pages 6-10Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.09.050
Keywords
Neurite-like process formation; Prickle; Dishevelled; PCP; Retinoic acid
Categories
Funding
- Ministry of Education, Science, Technology, Sports and Culture of Japan
Ask authors/readers for more resources
Murine Pricklel and Prickle2 belong to the planar cell polarity genes. Prickle2 but not Prickle1 gene expression was induced in C1300 neuroblastoma cells during neurite-like process formation induced by retinoic acid (RA). Over-expression of Pricklel or Prickle2 in C1300 cells induced striking neurite-like process formation in the absence of RA. Since Prickle binds to Dishevelled (Dvl) to induce its degradation in Drosophila, we examined the participation of Dvl protein in the neurite-like process formation of C1300 cells. Upon induction of the neurite-like process formation, the amount of Dvl1 protein decreased. Pricklel and Prickle2 could associate with Dvl1 and over-expression of Pricklel or Prickle2 resulted in the reduction of Dvl1 protein in C1300 cells. Furthermore, over-expression of Dvl1 in C1300 cells prevented the neurite-like process formation induced by Pricklel or Prickle2 over-expression. Thus, Pricklel and Prickle2 promote neurite-like process formation of C1300 cells via the Dvl1 dependent mechanism. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available