Journal
NEUROSCIENCE LETTERS
Volume 461, Issue 2, Pages 155-158Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2009.05.070
Keywords
Vitamin D; Development; Dopamine; COMT; Rat; Animal model
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Funding
- National Health and Medical Research Council of Australia
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There is growing evidence that low vitamin D impacts adversely on brain development. The current study investigated the impact of developmental vitamin D (DVD) deficiency on dopamine and serotonin metabolism in the neonatal rat brain. DVD-deficiency resulted in an altered dopaminergic metabolic profile in the forebrain, with a decrease in the conversion of dihydroxyphenylacetic acid (DOPAC) to homovanillic acid (HVA). Correspondingly, expression of the enzyme required for this conversion, catechol-O-methyl transferase (COMT), was decreased. These results suggest that DVD-deficiency influences dopamine turnover during development. Crown Copyright (C) 2009 Published by Elsevier Ireland Ltd. All rights reserved.
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